There are 10 safes hidden in Yakuza 6 that can be opened with a key. An additional safe can be be found and opened with the right combination.
Each of these safes has specific goodies like, xp boosters, money or equipment items that boost stats.
A key only opens one safe and does not unlock any safe. The keys and safes that belong together are always located close to each other.
6 04:08 (SAFE COMBINATION: KP56VFA9MX2B7LH)
YAKUZA 6 | All 10 Safe Key Locations (+Opening Secret Safe at Serena Rooftop)
YAKUZA 6 | How to find NEW SAFE COMBINATION (Serena Rooftop Safe Code/Combination)
YAKUZA 6 | All 19 CAT Locations (Completing the CAT CAFE Quest and finding all Cats)
YAKUZA 6 | How to Get Into NEW GAUDI Bar (Bar Conversation & Collecting Baseball Players)
YAKUZA 6 | All 30 MENU Combinations (Finding Meal Combos and Restaurants in Yakuza 6)
Yakuza 6 | UFO Easter Egg Locations (Getting the UFO Finder / Search for UFO/Aliens Easter Egg)